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Richter transformation remains an ominous occasion for individuals with CLL, specially when it is clonally connected to the initial CLL, mainly because Not one of the recently approved novel agents is actually effective. In fact, disease transformation is a comparatively frequent reason behind failure to gain from these drugs.ninety,128,129 Histological confirmation is always recommended because it can guideline prognosis (i.e., Hodgkin lymphoma and clonally unrelated tumors have a lot more favorable prognosis).

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